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Description
Nectin-4 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms PRR4,LNIR,Nectin cell adhesion molecule 4PVRL4,Ig superfamily receptor LNIRPoliovirus receptor related protein 4,NECTIN4,Poliovirus Receptor Related 4,Nectin 4,Nectin 4,EDSS1 Accession XP_005541277. 1 Amino Acid Sequence Gly32 Ser349, with C *8His Expression System HEK293 Molecular Weight 40 43kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical
Product Specification
| Species | Cynomolgus |
| Synonyms | PRR4,LNIR,Nectin cell adhesion molecule 4，PVRL4,Ig superfamily receptor LNIR，Poliovirus receptor-related protein 4,NECTIN4,Poliovirus Receptor-Related 4,Nectin-4,Nectin 4,EDSS1 |
| Accession | XP_005541277.1 |
| Amino Acid Sequence | Gly32-Ser349, with C-*8His |
| Expression System | HEK293 |
| Molecular Weight | 40-43kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Reymond, N. et al. (2001) J. Biol. Chem. 276:43205. 2.Takai, Y. et al. (2008) Nat. Rev. Mol. Cell Biol. 9:603. 3.Fabre, S. et al. (2002) J. Biol. Chem. 277:27006. |
Background
Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectin extracellular domains (ECDs) contain three Ig-like domains: an N-terminal V-type that mediates ligand binding, and two C2-type .Human Nectin-4 is normally expressed in the placenta, especially in endothelial cells, while in the mouse it is found in the embryo, lung, testis and brain. In humans, mutation of Nectin-4 has been correlated with ectodermal dysplasia-syndactyly syndrome,High Nectin-4/PVRL4 expression was associated with poor-prognosis in some invasive breast cancers and may be a new promising prognostic biomarker and specific therapeutic target.
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