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Description
TROP1/EpCAM His Tag Protein, MouseProduct Specification Species Mouse Synonyms TROP1, EpCAM, TACSTD1, CD326, DIAR5, EGP2, EGP314, EGP40, ESA, HNPCC8, HNPCC 8, KSA, M4S1, MIC18, MK1, GA733 2 Accession Q99JW5 Amino Acid Sequence Gln24 Thr266, with C terminal His Expression System HEK293 Molecular Weight 33 38kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at
Product Specification
| Species | Mouse |
| Synonyms | TROP1, EpCAM, TACSTD1, CD326, DIAR5, EGP2, EGP314, EGP40, ESA, HNPCC8, HNPCC-8, KSA, M4S1, MIC18, MK1, GA733-2 |
| Accession | Q99JW5 |
| Amino Acid Sequence | Gln24-Thr266, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 33-38kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Brunner A. et al. (2008) EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. J Clin Pathol. 61(3):307-310. 2、Trzpis M. et al. (2008) EpCAM in morphogenesis. Front Biosci. 13: 5050-5055. 3、Munz M. et al. (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-5629. 4、Carpenter G. et al. (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell. 15(3): 165-166. |
Background
Epithelial Cellular Adhesion Molecule (EpCAM), also known as KS1/4, gp40, GA733-2, 17-1A, and TROP‑1, is a 40 kDa transmembrane glycoprotein that consists of a 242 amino acid (aa) extracellular domain with two EGF‑like repeats, a 23 aa transmembrane segment, and a 26 aa cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.
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4.7 ★★★★★
Based on 1314 reviews
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Product Reviews
★★★★★ 4
Super fun but fabric not durable for rough play.
Color: Blue
My dog absolutely love this, but the octopus cloth fell apart within the first day. He doesn’t usually play rough with his toys, but he was able to shred this octopus fabric very easily. He was very passionate in his playfulness and he’s a big dog, but he was able to put massive holes in the fabric within the first hour of play. The Ball still works, however so hopefully we can find another toy to stick it in.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 8, 2026
★★★★★ 5
My dog's favorite toy to date
Color: Blue
Heavy duty material that my dog has not destroyed. The vibrating ball inside is made of hard plastic, so beware if your dog likes to shake their toys, it definitely hurts to get whacked by this. The velcro keeping the ball inside is also heavy duty and takes a lot of strength to open. All in all, its a great toy and one of my dog's favorites.
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Reviewed in the United States on June 10, 2026
★★★★★ 3
Good enough.
Color: Blue
A little smaller than I thought and the battery doesn't last too long. But my puppy enjoys it enough. It is holding up well to her teeth as well.
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Reviewed in the United States on April 16, 2026
★★★★★ 5
My dog loves this toy!
Color: Green
I was NOT expecting my dog to like this toy, but she loves it! The legs are stretchy and the body vibrates. The battery lasts about a month.
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Reviewed in the United States on June 8, 2026
★★★★★ 5
Great interactive toy. Worth the price.
Color: Blue
Our Lab absolutely loves it. She throws it all over the house. It’s so fun to watch her play with it. It’s by far her favorite toy right now. It’s easy to charge and came with charging cable. It has a button to turn off and on and a couple different speeds. My parents got her a different one for Christmas and since she loved it so much we decided to get her another one. It’s pretty durable too. She normally rips through toys pretty quickly and both of the ones she has are still in good shape. No rips or tears. She hasn’t tried just chewing on it like she does her squeaky toys. She just throws it all around the house and chases it.
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Reviewed in the United States on March 17, 2026
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