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Description
TIM-3/HAVCR2 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms TIMD3, HAVCR2, FLJ14428, KIM3 Accession Q8TDQ0 Amino Acid Sequence Ser22 Arg200, with C terminal Human IgG1 Fc
Product Specification
| Species | Human |
| Synonyms | TIMD3, HAVCR2, FLJ14428, KIM3 |
| Accession | Q8TDQ0 |
| Amino Acid Sequence | Ser22-Arg200, with C-terminal Human IgG1 Fc SEVEYRAEVGQNAYLPCFYTPAAPGNLVPVCWGKGACPVFECGNVVLRTDERDVNYWTSRYWLNGDFRKGDVSLTIENVTLADSGIYCCRIQIPGIMNDEKFNLKLVIKPAKVTPAPTRQRDFTAAFPRMLTTRGHGPAETQTLGSLPDINLTQISTLANELRDSRLANDLRDSGATIRIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 65-80kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Geng H. et al. (2006) Soluble form of T cell Ig mucin 3 is an inhibitory molecule in T cell-mediated immune response. J Immunol. 176(3): 1411-1420. 2、Anderson A C. et al. (2006) TIM-3 in autoimmunity. Curr Opin Immunol. 18(6): 665-669. 3、Anderson D E. (2007) TIM-3 as a therapeutic target in human inflammatory diseases. Expert Opin Ther Targets. 11(8): 1005-1009. 4、Pan H F. et al. (2010) TIM-3 as a new therapeutic target in systemic lupus erythematosus. Mol Biol Rep. 37(1): 395-398. |
Background
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2, is a 60 kDa member of the TIM family of immune regulating molecules. TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk region. Mature mouse TIM-3 consists of a 174 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 67 aa cytoplasmic tail. Within the ECD, mouse TIM-3 shares 58% and 75% aa sequence identity with human and rat TIM-3, respectively. Recently, the identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. The TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear. In the tumor rejection model, the soluble form of Tim-3 (sTim-3) significantly impaired T cell antitumor immunity, evidenced by decreased antitumor CTL activity and reduced amount of tumor-infiltrating lymphocytes in the tumor.
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4.8 ★★★★★
Based on 1273 reviews
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Product Reviews
★★★★★ 5
Dogs love them
Style: Pack of 2 - 8 Ounce
My dogs have been having intestinal problems and these are perfect for giving them some safe with a great crunch. They love them.
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Reviewed in the United States on May 28, 2026
★★★★★ 5
These are great
Style: Pack of 2 - 8 Ounce
My puppy loves these, I will be paying again and again!
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Reviewed in the United States on May 30, 2026
★★★★★ 4
no dog would resit these...
Flavor Name: Braided Stick (Chicken)
My dogs loved them but they were a lot smaller than I imagined.
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Reviewed in the United States on February 26, 2026
★★★★★ 5
Turkey tendon, vitamin E, low in fat, and high in protein. A great little midday snack 😊
Flavor Name: Braided Stick (Chicken)
My dog really liked these iPaw Turkey Tendon Braided Sticks. Every time I gave her one she went nuts and destroyed it in less than 5 mins. She's 80 pounds and for most medium-large dogs it will be the same, they won't last long at all. But I imagine for much smaller dogs they'd probably be a good 10-15 min chew. They have a very mild and almost non-existent smell, and they texture is quite hard and firm, so I would be hesitant to let a dog with missing teeth have one. They may be a bit difficult to chew. My dog hasn't had any upset stomach or diarrhea issues after eating these, which is always something I can keep an eye out for when feeding her something new. So far so good! They've got turkey tendon and vitamin E which are both super nutritional for dogs, and they're low in fat and high in protein which is another huge plus. Especially if your dog has weight issues. They're pretty small and they don't last long, but that's ok, as long as my girl loves them and enjoys them that's all that matters to me. They make for a great little midday snack, and for only $14 I would absolutely purchase them again.
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Reviewed in the United States on March 22, 2026
★★★★★ 4
Chihuahua and Border Collie Approved
Flavor Name: Braided Stick (Chicken)
We got the iPaw Turkey Tendon Braided Sticks for our two senior pooches, and it’s safe to say they are an absolute hit in our household.
Both of our dogs seem to genuinely love the flavor and the "chew" of these. They stayed engaged with the treat until the very last bit was gone.
While they are hard, they aren't rock-hard. I was easily able to cut them up with scissors for our Chihuahua, who is missing several teeth. He was able to gum them down without any issues, which is a win for a pup with dental challenges.
The only reason I’m giving these 4 stars instead of 5 is the price. They are definitely on the expensive side for the amount you get. Since my dogs go through them so quickly, it’s hard to justify keeping these as a "constant" staple in the pantry, but they make for an excellent occasional high-value treat.
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Reviewed in the United States on March 10, 2026