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Description
PLA2R1 His Tag Protein, HumanProduct Specification Species Human Synonyms PLA2R1, CLEC13C, M type receptor, PLA2IR, PLA2 R, PLA2G1R, PLA2R Accession Q13018 Amino Acid Sequence Glu21 Ser1397, with C terminal 10*His
Product Specification
| Species | Human |
| Synonyms | PLA2R1, CLEC13C, M-type receptor, PLA2IR, PLA2-R, PLA2G1R, PLA2R |
| Accession | Q13018 |
| Amino Acid Sequence | Glu21-Ser1397, with C-terminal 10*His EGVAAALTPERLLEWQDKGIFVIQSESLKKCIQAGKSVLTLENCKQANKHMLWKWVSNHGLFNIGGSGCLGLNFSAPEQPLSLYECDSTLVSLRWRCNRKMITGPLQYSVQVAHDNTVVASRKYIHKWISYGSGGGDICEYLHKDLHTIKGNTHGMPCMFPFQYNHQWHHECTREGREDDLLWCATTSRYERDEKWGFCPDPTSAEVGCDTIWEKDLNSHICYQFNLLSSLSWSEAHSSCQMQGGTLLSITDETEENFIREHMSSKTVEVWMGLNQLDEHAGWQWSDGTPLNYLNWSPEVNFEPFVEDHCGTFSSFMPSAWRSRDCESTLPYICKKYLNHIDHEIVEKDAWKYYATHCEPGWNPYNRNCYKLQKEEKTWHEALRSCQADNSALIDITSLAEVEFLVTLLGDENASETWIGLSSNKIPVSFEWSNDSSVIFTNWHTLEPHIFPNRSQLCVSAEQSEGHWKVKNCEERLFYICKKAGHVLSDAESGCQEGWERHGGFCYKIDTVLRSFDQASSGYYCPPALVTITNRFEQAFITSLISSVVKMKDSYFWIALQDQNDTGEYTWKPVGQKPEPVQYTHWNTHQPRYSGGCVAMRGRHPLGRWEVKHCRHFKAMSLCKQPVENQEKAEYEERWPFHPCYLDWESEPGLASCFKVFHSEKVLMKRTWREAEAFCEEFGAHLASFAHIEEENFVNELLHSKFNWTEERQFWIGFNKRNPLNAGSWEWSDRTPVVSSFLDNTYFGEDARNCAVYKANKTLLPLHCGSKREWICKIPRDVKPKIPFWYQYDVPWLFYQDAEYLFHTFASEWLNFEFVCSWLHSDLLTIHSAHEQEFIHSKIKALSKYGASWWIGLQEERANDEFRWRDGTPVIYQNWDTGRERTVNNQSQRCGFISSITGLWGSEECSVSMPSICKRKKVWLIEKKKDTPKQHGTCPKGWLYFNYKCLLLNIPKDPSSWKNWTHAQHFCAEEGGTLVAIESEVEQAFITMNLFGQTTSVWIGLQNDDYETWLNGKPVVYSNWSPFDIINIPSHNTTEVQKHIPLCALLSSNPNFHFTGKWYFEDCGKEGYGFVCEKMQDTSGHGVNTSDMYPMPNTLEYGNRTYKIINANMTWYAAIKTCLMHKAQLVSITDQYHQSFLTVVLNRLGYAHWIGLFTTDNGLNFDWSDGTKSSFTFWKDEESSLLGDCVFADSNGRWHSTACESFLQGAICHVPPETRQSEHPELCSETSIPWIKFKSNCYSFSTVLDSMSFEAAHEFCKKEGSNLLTIKDEAENAFLLEELFAFGSSVQMVWLNAQFDGNNETIKWFDGTPTDQSNWGIRKPDTDYFKPHHCVALRIPEGLWQLSPCQEKKGFICKMEADIHTAEALPEKGPSHSGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 150-180kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Radice A. et al. (2016) Clinical usefulness of autoantibodies to M-type phospholipase A2 receptor (PLA2R) for monitoring disease activity in idiopathic membranous nephropathy (IMN). Autoimmunity reviews. 15(2). |
Background
Autoantibodies to M-type phospholipase A2 receptor (PLA2R) are specific markers of idiopathic membranous nephropathy (IMN). They can differentiate IMN from other glomerular diseases and primary from secondary forms of MN. There was a statistically significant association between changes in PLA2R antibody levels and the clinical course of PLA2R-positive IMN. The positive PLA2R serum antibody status was linearly associated with increasing proteinuria and decreasing serum albumin over time, compared with negative antibody status. Moreover, the strong correlation between the clinical conditions and PLA2R antibody levels allowed the prediction of prevalence distribution of patients with active disease, partial and complete remission. Data suggest that continuous evaluation of anti-PLA2R antibodies contributes to the optimal timing and duration of immunosuppressive therapy, reducing over (under) treatment and associated side effects.
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4.4 ★★★★★
Based on 2497 reviews
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Product Reviews
★★★★★ 1
Unsafe product falls apart in chunks, choking hazard
Color: Brown & Grey
I bought these toys for my small 11 pound dog
The product fell apart within a couple hours both this is it’s not meant for the description as a durable toy. It comes up in chunks and can cause choking. I returned the toys to make a point that I’m not gonna buy a product that can hold my pet and it’s unsafe for the advertise use.
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Reviewed in the United States on May 12, 2026
★★★★★ 4
good giraffe
Color: Orange & Orange
my dogs are insane and the fox one didn’t last as long as the giraffe but it’s still holding up well after 6? months. worth my money
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 20, 2025
★★★★★ 5
Keeps dogs busy
Pups love these. Hide treats in them and they’re good to go.
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Reviewed in the United States on April 8, 2026
★★★★★ 3
Cute toy for small dogs
Color: Orange & Orange
The toys are cute and well priced. The rope is sturdy but the fabric areas are easily ripped. I had to throw them out after my 5 mo puppy Boston terrier ripped it with 15 minutes… oh well!
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Reviewed in the United States on May 5, 2026
★★★★★ 5
perfect for my teething puppy
Color: Brown & Grey, Color: Brown & Grey
these are great my puppy loves them!! these are perfect for his teething
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Reviewed in the United States on April 14, 2026