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Description
Biotinylated CA125/MUC16 His&Avi Tag Protein, HumanProduct Specification Species Human Synonyms CA125, CA 125, MUC 16, FLJ14303, MUC16, mucin 16, mucin 16 Accession Q8WXI7 Amino Acid Sequence Pro13810 Pro14451, with C terminal His and Avitag Expression System HEK293 Molecular Weight 95 115kDa (Reducing) Purity 95% by SDS PAGE & >90% by SEC HPLC Endotoxin <0. 1EU g Tag Avi Tag, His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, 5% trehalose, PH7. 4 Reconstitution Reconstitute at 0. 1 1
Product Specification
| Species | Human |
| Synonyms | CA125, CA-125, MUC-16, FLJ14303, MUC16, mucin 16, mucin-16 |
| Accession | Q8WXI7 |
| Amino Acid Sequence | Pro13810-Pro14451, with C-terminal His and Avitag |
| Expression System | HEK293 |
| Molecular Weight | 95-115kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & >＞90% by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 5% trehalose, PH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Hires M et al. Glycan signatures for the identification of cisplatin-resistant testicular cancer cell lines: Specific glycoprofiling of human chorionic gonadotropin (hCG). Cancer Med 11:968-982 (2022) |
Background
The CA125, also known as the MUC16, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. However，due to lack of sensitivity for stage I disease and lack of specificity, it is of little value in the detection of early ovarian cancer. Due to its similarly elevated levels in some nonmalignant conditions, it is not specific enough to be used for population screening. It is thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. The CA 125 molecule is almost certainly a glycoprotein with a predominance of O-linkages. It is heterogeneous with regard to both size and charge, most likely due to continuous deglycosylation of side chains during its life-span in bodily fluids. It exists as a very large complex (perhaps as much as 4 million daltons) under natural conditions.
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