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Description
Endoglin/CD105 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms Endoglin,CD105,ENG,END Accession P17813 1 Amino Acid Sequence Glu26 Gly586, with C hIgG1 Fc Expression System HEK293 Molecular Weight 90 95kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Physical Appearance Lyophilized Powder Storage Buffer 1*PBS, pH7. 4,5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Human |
| Synonyms | Endoglin,CD105,ENG,END |
| Accession | P17813-1 |
| Amino Acid Sequence | Glu26-Gly586, with C-hIgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 90-95kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 1*PBS, pH7.4,5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.MINI REVIEW article Front. Med., 30 January 2019 Sec. Translational Medicine Volume 6 - 2019 | https://doi.org/10.3389/fmed.2019.00010. |
Background
Endoglin (ENG), endothelial glycoprotein, also known as CD105, is a coreceptor of the transforming growth factor-β (TGFβ) family signaling complex, which is highly expressed on endothelial cells and plays a key role in angiogenesis. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. As a TGF-beta coreceptor, CD105/Endoglin activates SMAD transcription factors, participating in the TGF-beta/BMP signaling cascade.
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